The KETO-HF Trial

Associate Professor Sarah Zaman, University of Sydney

2023 Vanguard Grant - Two Year

Years funded: 2024 - 2025

While there have been many advancements in the treatment of heart failure, people with the condition still face significant health problems and shorter life-expectancies. Exciting early research suggests that a ketogenic diet may be an effective treatment for heart failure, whereby a failing heart can switch to ketone bodies to produce energy, with improvement in heart function.

The 'Ketogenic Diet in Heart Failure with Reduced Ejection Fraction (KETO-HF) Trial' is a pilot study that will explore the effect of a ketogenic diet in people with heart failure, to see if it is safe and effective. Importantly, the pilot study will determine if there are signs that a ketogenic diet can prevent heart failure events, improve heart function and quality of life. The findings will be used to inform the design of a larger study.